Correlations between these regions and global tests of cognition (MMSE in n = 17, MoCA in n = 27, n = 14 in both) were performed. Brain volumes were compared to a normative database to determine the extent of atrophy. TBI documentation included head trauma mechanism. IRB approved review of medical records in patients with cognitive decline focused on those who had documented TBI histories and brain MRI scans after TBI (n = 40, 67.7☑4.5 years) with volumetric quantification by applying an FDA cleared software program.
To characterize regional brain volume loss in persons with TBI presenting with cognitive impairment. Brain MRI volumetric quantification can sensitively identify brain atrophy.
While traumatic brain injury (TBI) is recognized as a risk factor for dementia, there is lack of clinical tools to identify brain changes that may confer such vulnerability.
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